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Send EmailSodium Ascorbate, Sodium L-Ascorbate, Monosodium Ascorbate, Na-L-Ascorbate, E301, 134-03-2
SODIUM ASCORBATE
PRODUCT IDENTIFIER INFORMATION
| Parameter | Information |
|---|---|
| Product Name | Sodium Ascorbate |
| Chemical Name (IUPAC) | Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-olate |
| CAS Number | 134-03-2 |
| EC Number (EINECS) | 205-126-1 |
| Food Additive Code | E301 |
| Molecular Formula | C6H7NaO6 |
| Molecular Weight | 198.11 g/mol |
SECTION 1: CHEMICAL IDENTITY AND DESCRIPTION
| Parameter | Information |
|---|---|
| Chemical Name (IUPAC) | Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-olate |
| Systematic Name | L-Ascorbic Acid Sodium Salt; Vitamin C Sodium Salt |
| Synonyms | Sodium Ascorbate, Sodium L-Ascorbate, Monosodium Ascorbate, Vitamin C Sodium Salt, Na-L-Ascorbate |
| Abbreviations | NaAsc, SA |
| CAS Number | 134-03-2 |
| EC Number (EINECS) | 205-126-1 |
| Food Additive Code | E301 |
| INS Number | 301 |
| Molecular Formula | C6H7NaO6 |
| Molecular Weight | 198.11 g/mol |
| Chemical Class | Organic acid salt (sodium salt of L-ascorbic acid) |
| Vitamin C Activity | ~889 mg Vitamin C / 1000 mg Sodium Ascorbate |
| Physical State (20°C) | Solid (white or yellowish-white crystalline powder) |
| Odor | Odorless |
| Taste | Slightly salty, characteristic |
SECTION 2: PHYSICAL AND CHEMICAL PROPERTIES
| Property | Value | Test Method |
|---|---|---|
| Appearance | White or yellowish-white crystalline powder | Visual |
| Odor | Odorless | Olfactometric |
| Taste | Slightly salty, characteristic | Sensory |
| Molecular Weight | 198.11 g/mol | Calculated |
| Melting Point | ~218°C (with decomposition) | DSC |
| pH (5% solution, 25°C) | 7.0 – 8.0 (neutral-slightly alkaline) | pH Meter |
| pH (10% solution, 25°C) | 7.0 – 8.0 | pH Meter |
| Solubility in Water (25°C) | ~62 g/100 mL (high solubility) | Gravimetric |
| Solubility in Ethanol | Slightly soluble | General Method |
| Solubility in Methanol | Slightly soluble | General Method |
| Solubility in Isopropanol | Slightly soluble | General Method |
| Specific Optical Rotation ([α]20D) | +103° to +108° (c=5, H2O) | Polarimetry |
| Hygroscopicity | Moderate (absorbs moisture) | Visual |
| Stability (Solid) | Relatively stable | |
| Stability (Solution) | Rapidly oxidized by atmospheric oxygen; degrades with light and heat | |
| Flash Point | Non-flammable | Not applicable |
SECTION 3: CHEMICAL PROPERTIES AND REACTIVITY
| Parameter | Information |
|---|---|
| Chemical Character | Organic acid salt; reducing agent; antioxidant |
| Stability | Relatively stable in solid form; rapidly oxidized by atmospheric oxygen in aqueous solution |
| Oxidation | In aqueous solution: Sodium Ascorbate → Dehydroascorbic Acid (oxidized form) |
| Decomposition Products (Heating) | Above 218°C: CO, CO2, Na2O, water vapor |
| Incompatible Materials | Strong oxidizing agents, heavy metal ions (Cu2+, Fe3+), alkaline environments |
| Light Sensitivity | Light-sensitive; degrades in direct sunlight |
| Heat Sensitivity | Degrades at high temperatures |
| Difference from Ascorbic Acid | Lower acidity (pH ~7-8 vs ~2.5); more stomach-friendly |
| Hazardous Polymerization | Does not occur |
SECTION 4: VITAMIN C FORMS COMPARISON
| Property | Sodium Ascorbate (E301) | Ascorbic Acid (E300) | Calcium Ascorbate (E302) | Ascorbyl Palmitate (E304) |
|---|---|---|---|---|
| CAS Number | 134-03-2 | 50-81-7 | 5743-27-1 | 137-66-6 |
| Molecular Formula | C6H7NaO6 | C6H8O6 | C12H14CaO12 | C22H38O7 |
| pH (5% solution) | 7.0 – 8.0 | ~2.5 | 6.8 – 7.4 | Neutral (insoluble) |
| Acidic Character | Neutral (salt) | Acidic | Neutral (salt) | Neutral (ester) |
| Stomach-Friendly | Yes | No (acidic) | Yes | Yes |
| Solubility in Water | ~62 g/100 mL | ~33 g/100 mL | ~50 g/100 mL | Insoluble |
| Vitamin C Content | ~89% | ~100% | ~82% | ~42% |
| Sodium Content | ~11.6% | 0% | 0% | 0% |
| Fat Solubility | Insoluble | Insoluble | Insoluble | Soluble |
| Primary Use | Food, pharma, meat processing | Food, supplements | Supplement (low sodium) | Cosmetics, fatty foods |
SECTION 5: FUNCTIONAL PROPERTIES AND MECHANISM OF ACTION
| Property | Description |
|---|---|
| Antioxidant | Neutralizes free radicals; prevents oxidative damage; delays browning and staling in foods |
| Vitamin C Source | Highly bioavailable form of vitamin C; essential for collagen synthesis, immune function, iron absorption |
| Reducing Agent | Prevents oxidation in food and pharmaceutical formulations |
| Color Stabilizer | Color preservative in processed meat products (sausages, salami, ham); synergistic with nitrite/nitrate |
| Antimicrobial | Helps prevent microbial spoilage |
| Curing Agent | Curing accelerator in meat processing together with phosphates such as TSPP and STPP |
| Stomach-Friendly | Suitable vitamin C source for gastritis and reflux patients due to neutral pH |
| Parenteral Administration | Can be used as vitamin C source in intravenous infusion solutions |
SECTION 6: PRIMARY APPLICATION AREAS
| Sector / Application | Use | Typical Concentration / Dosage |
|---|---|---|
| Food - Processed Meat (Sausages, Salami, Ham) | Color stabilizer, curing agent | 0.05 – 0.2% |
| Food - Canned Fruits/Vegetables | Antioxidant, anti-browning agent | 0.05 – 0.3% |
| Food - Bakery Products | Antioxidant, shelf life extender | 0.05 – 0.2% |
| Food - Beverages (Fruit Juices) | Antioxidant, vitamin C fortification | 50 – 500 mg/L |
| Food - General Preservative | Antioxidant, antimicrobial | 0.05 – 0.3% |
| Pharmaceutical - Vitamin C Supplement | Tablets, capsules, effervescent, chewable | 100 – 1000 mg/dose |
| Pharmaceutical - Parenteral Nutrition | Intravenous infusion solution | Per clinical protocol |
| Pharmaceutical - Oncology (High Dose) | Intravenous vitamin C therapy (under medical supervision) | 25 – 100 g/cycle |
| Cosmetic - Skincare | Antioxidant, collagen support | 1 – 5% |
SECTION 7: QUALITY SPECIFICATIONS (FOOD/PHARMACEUTICAL GRADE - USP/EP/FCC)
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | White or yellowish-white crystalline powder | Visual |
| Odor | Odorless | Olfactometric |
| Purity (C6H7NaO6, Dry Basis) | 99.0 – 101.0% | Iodometric Titration / HPLC |
| Specific Optical Rotation ([α]20D) | +103° to +108° (c=5, H2O) | Polarimetry |
| pH (5% solution, 25°C) | 7.0 – 8.0 | pH Meter |
| Loss on Drying (105°C, 2 hours) | ≤ 0.5% | Gravimetric |
| Heavy Metals (as Pb) | ≤ 10 ppm | ICP-MS |
| Lead (Pb) | ≤ 2 ppm | ICP-MS |
| Arsenic (As) | ≤ 3 ppm | ICP-MS |
| Mercury (Hg) | ≤ 1 ppm | ICP-MS |
| Cadmium (Cd) | ≤ 1 ppm | ICP-MS |
| Iron (Fe) | ≤ 20 ppm | AAS |
| Copper (Cu) | ≤ 10 ppm | AAS |
| Oxalate | ≤ 0.1% | HPLC |
| Sulfate (SO4 2-) | ≤ 0.01% | Turbidimetric |
| Total Microbial Count | ≤ 1,000 CFU/g | USP <61> |
| Yeast and Mold | ≤ 100 CFU/g | USP <61> |
| E. coli | Negative in 10g | USP <62> |
| Salmonella spp. | Negative in 25g | USP <62> |
SECTION 8: TOXICOLOGICAL PROFILE
| Parameter | Value |
|---|---|
| Acute Oral Toxicity (LD50, Rat) | > 5,000 mg/kg (very low toxicity) |
| Acute Dermal Toxicity (LD50, Rabbit) | > 2,000 mg/kg |
| Skin Irritation | Not irritating |
| Eye Irritation | Mild mechanical irritation (dust) |
| Respiratory Irritation | Inhalation of dust may cause mechanical irritation |
| Carcinogenicity | Not classified |
| Mutagenicity | Negative in in vitro tests |
| Reproductive Toxicity | No known adverse effects |
| Chronic Toxicity | Gastrointestinal discomfort, diarrhea at high doses |
| Tolerable Upper Intake Level (UL) | 2000 mg/day Vitamin C for adults |
| GRAS Status | Recognized as GRAS by FDA |
SECTION 9: GHS CLASSIFICATION AND LABELING
GHS Classification (compliant with 1272/2008/EC):
| Hazard Class | Category | H-Statement |
|---|---|---|
| Not classified | - | Not classified as hazardous according to current regulations |
Signal Word: No signal word
Hazard Pictograms: No pictograms required
Precautionary Statements:
| Code | Statement |
|---|---|
| P261 | Avoid breathing dust |
| P280 | Wear protective goggles (in dusty environments) |
SECTION 10: FIRST AID MEASURES
| Exposure Route | Action to Take |
|---|---|
| Inhalation | Move to fresh air. Seek medical attention if respiratory irritation persists. |
| Skin Contact | Wash with plenty of water and soap. |
| Eye Contact | Rinse immediately with plenty of water for at least 15 minutes. Remove contact lenses if present. Seek medical attention if irritation persists. |
| Ingestion | Rinse mouth with water. Drink plenty of water. Seek medical attention if you feel unwell. |
SECTION 11: FIREFIGHTING MEASURES
| Parameter | Information |
|---|---|
| Fire Hazard | Non-flammable |
| Hazards During Fire | Above 218°C: CO, CO2, Na2O |
| Suitable Extinguishing Media | Any extinguishing media appropriate for surrounding fire |
| Special Protective Equipment | Self-contained breathing apparatus (SCBA), full protective clothing |
SECTION 12: STORAGE AND SHELF LIFE
| Parameter | Information |
|---|---|
| Storage Conditions | Cool (15-25°C), dry, well-ventilated area; protect from direct sunlight |
| Container Requirements | Tightly closed, airtight (oxygen-impermeable), light-resistant containers |
| Keep Away From | Oxygen (air), light, heat, moisture, heavy metal ions |
| Shelf Life | 24 months (unopened original packaging under appropriate storage conditions) |
| Stability Note | Relatively stable in solid form; rapidly degrades in aqueous solution with atmospheric oxygen; prepare solutions fresh |
SECTION 13: PACKAGING OPTIONS
| Packaging Type | Quantity | Material |
|---|---|---|
| Aluminum foil pouch (light and oxygen-proof) | 1 kg | Laminated aluminum |
| Aluminum foil pouch (light and oxygen-proof) | 5 kg | Laminated aluminum |
| Kraft bag with PE inner liner (light-protected) | 25 kg | Kraft paper + PE |
| Fiber drum (light-protected) | 25-50 kg | Fiberboard + PE |
SECTION 14: TRANSPORTATION INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not regulated (not hazardous) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| ADR/RID | Not regulated |
| IMDG Code | Not regulated |
| IATA (Air) | Not regulated |
| Marine Pollutant | No |
| Transport Temperature | Ambient; protect from light, moisture, and oxygen |
SECTION 15: REGULATORY STATUS
| Region / Authority | Status |
|---|---|
| European Union | Food additive E301; approved for use quantum satis |
| USA (FDA) | GRAS; approved as food additive and dietary supplement |
| USP-NF | Official monograph (USP Sodium Ascorbate) |
| European Pharmacopoeia | Official monograph (Ph. Eur. Sodium Ascorbate) |
| JECFA (FAO/WHO) | ADI not limited |
| Turkey | Approved under Turkish Food Codex Regulation on Food Additives |
| Halal / Kosher / Vegan | Available |
SECTION 16: OTHER NAMES AND SYNONYMS
| Type | Name |
|---|---|
| Common Names | Sodium Ascorbate, Sodium L-Ascorbate, Monosodium Ascorbate, Vitamin C Sodium Salt |
| Chemical Names | L-Ascorbic Acid Sodium Salt |
| Food Additive Code | E301, INS 301 |
| CAS Number | 134-03-2 |
| EC Number | 205-126-1 |
SECTION 17: SUMMARY TABLE
| Parameter | Value |
|---|---|
| Product | Sodium Ascorbate |
| CAS Number | 134-03-2 |
| Food Additive Code | E301 |
| Molecular Formula | C6H7NaO6 |
| Molecular Weight | 198.11 g/mol |
| Appearance | White or yellowish-white crystalline powder |
| pH (5% solution) | 7.0 – 8.0 |
| Solubility in Water (25°C) | ~62 g/100 mL |
| Primary Function | Antioxidant, vitamin C source, color stabilizer, curing agent |
| Shelf Life | 24 months |
| GHS Signal Word | Not classified |
SECTION 18: CRITICAL WARNINGS AND BEST PRACTICES
CRITICAL WARNINGS:
-
Oxygen Sensitivity: Rapidly oxidized by atmospheric oxygen in aqueous solution. Prepare solutions fresh and store in airtight containers.
-
Light Sensitivity: Light-sensitive; store in light-resistant containers.
-
Heat Sensitivity: Degrades at high temperatures; store in cool environment.
-
Metal Ions: Heavy metal ions (Cu2+, Fe3+) catalyze oxidation; do not store in metal containers.
-
Sodium Content: Contains ~11.6% sodium; use caution in patients requiring low sodium diet.
BEST PRACTICE RECOMMENDATIONS:
-
Solution Preparation: Prepare aqueous solutions fresh and use immediately; keep under inert atmosphere (N2) for long-term storage.
-
Meat Processing: Use at 0.05-0.2% in sausages, salami, and ham; provides synergistic effect with TSPP and STPP.
-
Vitamin C Supplementation: Ideal for gastritis and reflux patients as a stomach-friendly form.
-
Storage: Store in airtight, light-resistant containers in a cool and dry environment.
-
Packaging: After opening, transfer remaining product to airtight containers and consume within a short time.
LEGAL DISCLAIMER:
The information provided in this document is presented in good faith based on our current knowledge and experience; however, since all usage conditions are beyond our control, it does not constitute a binding specification or warranty. This Technical Data Sheet is for informational purposes only and does not constitute medical advice. Users are obligated to test the suitability for their own applications. For complete safety, storage, handling, transportation, disposal, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. This product is not intended to diagnose, treat, cure, or prevent any disease.
