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Send EmailTricalcium Phosphate, Calcium Phosphate Tribasic, Calcium Ortho Phosphate, Calcium Phosphate, E341, TCP, 7758-87-4, 10103-46-5, 12167-74-7
TRICALCIUM PHOSPHATE – TRİKALSIYUM FOSFAT
CAS Number: 7758-87-4 (TCP), 10103-46-5, 12167-74-7
EC Number (EINECS): 231-840-8
Molecular Formula: Ca₃(PO₄)₂
Molecular Weight: 310.18 g/mol
E Number: E341(iii)
SECTION 1: CHEMICAL IDENTITY AND DEFINITION
| Parameter | Information |
|---|---|
| Chemical Name (IUPAC) | Tricalcium phosphate |
| Other Names | Calcium Phosphate, Calcium Orthophosphate, Calcium Phosphate Tribasic, Tribasic Calcium Phosphate, TCP, Beta-TCP |
| Chemical Formula | Ca₃(PO₄)₂ |
| Molecular Weight | 310.18 g/mol |
| CAS Number | 7758-87-4 |
| EC Number (EINECS) | 231-840-8 |
| E Number | E341(iii) (Food additive) |
| Chemical Class | Inorganic calcium salt (phosphate) |
| Appearance | White, odorless, tasteless, crystalline powder |
| Odor | Odorless |
| Taste | Tasteless |
| Physical State (20°C) | Solid (powder) |
| Calcium Content | ~38.8% |
| Phosphorus Content | ~20.0% |
SECTION 2: PHYSICAL PROPERTIES
| Property | Value |
|---|---|
| Appearance | White, odorless, tasteless, crystalline powder |
| Odor | Odorless |
| Taste | Tasteless |
| Molecular Weight | 310.18 g/mol |
| Density | 3.14 g/cm³ |
| Melting Point | 1670 °C |
| Solubility in Water (20°C) | Moderate (slightly soluble) |
| Solubility in Dilute Acids | Soluble (HCl, HNO₃) |
| Solubility in Alcohol | Insoluble |
| Solubility in Acetic Acid | Insoluble |
| Temperature Solubility | Solubility decreases with increasing temperature; precipitation occurs |
| pH (suspension) | 6.0 – 8.0 |
| Calcium/Phosphorus Ratio | 1.94 (Ca/P) |
SECTION 3: TYPES OF CALCIUM PHOSPHATE
| Type | E Number | CAS Number | Formula | Description |
|---|---|---|---|---|
| Monocalcium Phosphate (MCP) | E341(i) | 10031-30-8 | Ca(H₂PO₄)₂ | Acidic form; used in baking powders |
| Dicalcium Phosphate (DCP) | E341(ii) | 7757-93-9 | CaHPO₄ | Neutral form; tablet filler |
| Tricalcium Phosphate (TCP) | E341(iii) | 7758-87-4 | Ca₃(PO₄)₂ | Basic form; anti-caking agent |
SECTION 4: CHEMICAL PROPERTIES
| Property | Information |
|---|---|
| Chemical Formula | Ca₃(PO₄)₂ |
| Molecular Weight | 310.18 g/mol |
| Chemical Class | Inorganic calcium salt (phosphate) |
| Structure | 3 calcium atoms + 2 phosphate groups |
| Calcium Content | ~38.8% |
| Phosphorus Content | ~20.0% |
| pH (suspension) | 6.0 – 8.0 |
| Stability | Stable compound (non-reactive) |
| Thermal Stability | Stable up to 1670°C |
| Incompatible Materials | Strong acids, strong bases |
Chemical Structure:
Ca₃(PO₄)₂
3 Ca²⁺ + 2 PO₄³⁻ → Ca₃(PO₄)₂
SECTION 5: FOOD INDUSTRY APPLICATIONS (E341(iii))
| Application | Function |
|---|---|
| Anti-Caking Agent | Improves flowability in powdered foods; prevents caking |
| Calcium and Phosphorus Source | Mineral supplementation |
| Acidity Regulator | pH control in foods |
| Leavening Agent | Baking powders for baked goods |
| Firming Agent | Texture stabilization in canned vegetables |
| Clouding Agent | Provides opacity in beverages |
| Humectant | Moisture control in sugar and salt |
| Mineral Salt Source | Cheese production |
| Reduced-Fat Products | Provides softness and opacity |
SECTION 6: PHARMACEUTICAL AND MEDICAL APPLICATIONS
| Application | Function |
|---|---|
| Calcium Supplementation | Treatment of calcium deficiency |
| Bone Grafting | Beta-TCP in bone regeneration |
| Dental Implants | Bone healing and regeneration |
| Tablet Filler | Compacting agent in tablet production |
| Vegan Calcium Source | Plant-based supplements |
SECTION 7: COSMETIC AND PERSONAL CARE APPLICATIONS
| Application | Function |
|---|---|
| Toothpastes | Strengthens tooth enamel; calcium supplementation |
| Baby Powder | Anti-caking agent |
| Teat Disinfectants | For dairy animals |
SECTION 8: INDUSTRIAL APPLICATIONS
| Application | Function |
|---|---|
| Fertilizer Production | Phosphorus source |
| Ceramics and Porcelain | Coating and production |
| Water Filtration | Insolubility in water provides advantage |
| Frying Oils | Stabilizer |
| Wine Industry | Fermentation tablets |
SECTION 9: QUALITY SPECIFICATIONS (FOOD GRADE)
| Parameter | Specification (FCC / USP) |
|---|---|
| Appearance | White, crystalline powder |
| Identification | Positive (Calcium and Phosphate tests) |
| Assay (Ca₃(PO₄)₂) | 98.0 – 102.0% |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 1.0% |
| pH (suspension) | 6.0 – 8.0 |
| Chlorides (Cl) | ≤ 0.02% |
| Sulfates (SO₄) | ≤ 0.02% |
| Heavy Metals (as Pb) | ≤ 10 ppm |
| Lead (Pb) | ≤ 2 ppm |
| Arsenic (As) | ≤ 3 ppm |
| Mercury (Hg) | ≤ 1 ppm |
| Cadmium (Cd) | ≤ 1 ppm |
| Barium (Ba) | ≤ 0.01% |
| Water Insoluble | ≤ 0.2% |
SECTION 10: MICROBIOLOGICAL SPECIFICATIONS
| Parameter | Specification |
|---|---|
| Total Aerobic Mesophilic Bacteria | ≤ 1,000 CFU/g |
| Yeast and Mold | ≤ 100 CFU/g |
| Salmonella spp. | Negative in 25g |
| Escherichia coli | Negative in 10g |
SECTION 11: STORAGE AND SHELF LIFE
| Parameter | Information |
|---|---|
| Storage Conditions | Cool (15-25°C), dry, well-ventilated area |
| Container Requirements | Tightly closed, original packaging |
| Protect From | Moisture, strong acids, strong bases |
| Shelf Life | 36-60 months (unopened original packaging) |
SECTION 12: PACKAGING OPTIONS
| Packaging Type | Quantity | Material |
|---|---|---|
| PE-lined kraft paper bag | 25 kg | Kraft paper + PE |
| Plastic pail | 20-25 kg | HDPE |
| Fiber drum | 25-50 kg | HDPE + PE |
| Big-Bag | 500-1000 kg | Polypropylene (with PE liner) |
SECTION 13: SAFETY AND HEALTH INFORMATION
GHS Classification (Bulk Powder)
| Hazard Class | Category |
|---|---|
| Not classified as hazardous | - |
Hazard Statements
| Code | Statement |
|---|---|
| None | Not classified as hazardous |
Precautionary Statements
| Code | Statement |
|---|---|
| P261 | Avoid breathing dust |
| P280 | Wear protective gloves/eye protection |
| P305+P351+P338 | IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing |
SECTION 14: TOXICOLOGICAL INFORMATION
| Parameter | Value |
|---|---|
| Oral LD50 (Rat) | > 5,000 mg/kg |
| ADI (Acceptable Daily Intake) | 70 mg/kg body weight/day (as phosphate) |
| Carcinogenicity | Not classified |
| Mutagenicity | Negative in standard tests |
| FDA GRAS | 21 CFR 182.8217 |
SECTION 15: FIRST AID MEASURES
| Exposure Route | Action |
|---|---|
| Inhalation | Move to fresh air. If respiratory irritation persists, seek medical attention. |
| Skin Contact | Wash with plenty of soap and water. |
| Eye Contact | Rinse immediately with plenty of water for at least 15 minutes. Seek medical attention. |
| Ingestion | Rinse mouth. Drink plenty of water. Seek medical attention. |
SECTION 16: REGULATORY STATUS
| Region / Authority | Status |
|---|---|
| European Union | Approved as E341(iii) |
| USA (FDA) | GRAS (21 CFR 182.8217) |
| Turkey | Approved (Turkish Food Codex) |
| JECFA (FAO/WHO) | Approved; ADI: 70 mg/kg bw/day |
| Codex Alimentarius | Approved (INS 341(iii)) |
| USP | Monograph available |
| Ph. Eur. | Monograph available |
SECTION 17: TRANSPORT INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not regulated (not dangerous goods) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| ADR/RID | Not regulated |
| IMDG Code | Not regulated |
| IATA (Air) | Not regulated |
| Marine Pollutant | No |
SECTION 18: FIRE-FIGHTING MEASURES
| Parameter | Information |
|---|---|
| Fire Hazard | Non-combustible (inorganic salt) |
| Suitable Extinguishing Media | Water spray (mist), CO₂, dry chemical powder |
| Specific Hazards | When heated, emits calcium oxide and phosphorus oxide fumes |
| Decomposition Products | CaO, P₂O₅ |
| Protective Equipment | Self-contained breathing apparatus (SCBA), full protective clothing |
SECTION 19: ACCIDENTAL SPILLAGE AND CLEANUP
| Parameter | Information |
|---|---|
| Personal Protection | Nitrile gloves, protective goggles, dust mask (N95) |
| Cleaning Methods | Sweep or vacuum; avoid dust generation |
| Environmental Precautions | Prevent entry into drains, soil, and surface waters |
| Waste Disposal | According to local regulations; landfilling at licensed facilities |
SECTION 20: OTHER NAMES AND SYNONYMS
| Type | Name |
|---|---|
| Turkish Names | Trikalsiyum Fosfat, Kalsiyum Fosfat, Tribazik Kalsiyum Fosfat |
| English Names | Tricalcium Phosphate, Calcium Phosphate, Calcium Orthophosphate, Calcium Tertiary Phosphate, TCP |
| Chemical Names | Calcium Orthophosphate, Phosphoric Acid Calcium Salt (2:3) |
| Abbreviations | TCP |
| E Number | E341(iii) |
| CAS Number | 7758-87-4 |
SECTION 21: SUMMARY AND CRITICAL NOTES
Product Summary
| Parameter | Value |
|---|---|
| Product | Tricalcium Phosphate (TCP) |
| CAS Number | 7758-87-4 |
| E Number | E341(iii) |
| Appearance | White, odorless, tasteless crystalline powder |
| Molecular Weight | 310.18 g/mol |
| Primary Function | Anti-caking agent, calcium source |
| ADI | 70 mg/kg body weight/day |
Critical Notes
-
Three Forms: E341 exists in three different forms: Monocalcium Phosphate [E341(i)], Dicalcium Phosphate [E341(ii)], and Tricalcium Phosphate [E341(iii)].
-
Most Common Form: Tricalcium Phosphate (TCP) is the most commonly used form in the food industry as an anti-caking agent and calcium source.
-
Slightly Soluble: Moderately soluble in water; solubility decreases with increasing temperature.
-
Calcium Source: Contains ~38.8% calcium and ~20.0% phosphorus.
-
Anti-Caking Agent: Improves flowability in powdered foods (spices, powdered beverages).
-
Bone Health: Beta-TCP form is used in bone grafting and regeneration.
-
ADI: Acceptable daily intake is 70 mg/kg body weight/day (as phosphate).
-
Suitable for All Diets: Not derived from animal sources; suitable for vegetarian and vegan diets.
-
GRAS: Approved as GRAS by FDA (21 CFR 182.8217).
-
Regulatory Status: Approved in EU (E341(iii)), FDA, JECFA, and Turkish Food Codex.
IMPORTANT DECLARATION: This Technical Data Sheet (TDS) is for informational purposes only and has been prepared based on available technical data. The user is responsible for determining the product's suitability for their specific application and for complying with all local, national, and international regulations. For complete safety, storage, use, transport, waste, and regulatory compliance information, refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier.
