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Send EmailCalcium Propionate, Calcium Propanoate, Calcium Dipropanoate, E282, 4075-81-4
CALCIUM PROPIONATE (E282)
CAS Number: 4075-81-4
EC Number (EINECS): 223-795-8
Molecular Formula: C₆H₁₀CaO₄
Molecular Weight: 186.22 g/mol
Chemical Class: Organic acid salt (carboxylate)
E Number: E282
SECTION 1: PRODUCT IDENTIFICATION AND CHEMICAL IDENTITY
| Parameter | Description |
|---|---|
| Chemical Name (IUPAC) | Calcium propanoate |
| Other Names | Calcium Propionate, Calcium Propanoate, Calcium Dipropanoate, Propanoic Acid Calcium Salt, Propionic Acid Calcium Salt Hydrate |
| CAS Number | 4075-81-4 |
| EC Number (EINECS) | 223-795-8 |
| E Number | E282 |
| Molecular Formula | C₆H₁₀CaO₄ |
| Molecular Weight | 186.22 g/mol |
| Chemical Class | Organic acid salt (carboxylate) |
| Structure | (CH₃CH₂COO)₂Ca |
| Appearance | White powder or monoclinic crystals |
| Odor | Faint, mild characteristic |
| pH (Aqueous solution) | 6.0 – 9.0 |
SECTION 2: PHYSICAL AND CHEMICAL PROPERTIES
| Property | Value / Range |
|---|---|
| Molecular Formula | C₆H₁₀CaO₄ |
| Molecular Weight | 186.22 g/mol |
| Appearance | White powder or monoclinic crystals |
| Odor | Faint, mild characteristic |
| Melting Point | ~300°C (decomposes) |
| Density | ~1.40 g/cm³ |
| Solubility in Water | 1 g/10 mL (good solubility) |
| Solubility in Ethanol | Slightly soluble |
| pH (Aqueous solution) | 6.0 – 9.0 |
| Hygroscopicity | Hygroscopic (absorbs moisture) |
| Stability | Stable at room temperature |
| Thermal Decomposition | Decomposes when heated; releases acidic and irritant fumes |
| Storage Temperature | < 30°C |
| Incompatibilities | Strong oxidizers |
SECTION 3: CHEMICAL PROPERTIES AND REACTIONS
| Property | Description |
|---|---|
| Chemical Class | Organic acid salt (carboxylate) |
| Functional Group | Carboxylate (-COO⁻) |
| Reactivity | Low under normal conditions |
| Acidic Medium | Releases free propionic acid (antifungal effect) |
| Thermal Decomposition | > 300°C decomposes; releases acidic fumes |
| Hygroscopicity | Absorbs moisture |
| Incompatibilities | Strong oxidizers |
3.1. Antimicrobial Mechanism
Calcium propionate hydrolyzes to free propionic acid in acidic media:
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Free Propionic Acid: Antibacterial effect on Aspergillus niger and gas bacilli
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Fungal Inhibition: Stronger than acetic acid, weaker than sorbic acid
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Yeast Effect: Limited effect on yeast (reason for preference in bakery products)
SECTION 4: MAJOR APPLICATIONS AND END-USES
4.1. Food Industry (Most Important Application)
| Application | Function | Suitability |
|---|---|---|
| Bread and Bakery Products | Preservative, mold inhibitor | High |
| Processed Meat Products | Preservative, shelf-life extender | High |
| Dairy Products and Cheese | Preservative, nutritional supplement | High |
| Whey | Preservative | High |
| Dough / Pastry | Moisture and pH control, mold inhibitor | High |
| Low-Yeast Bakery Products | Preservative | High |
| Beverages | Inhibiting agent (microorganism prevention) | High |
4.2. Animal Feed and Veterinary
| Application | Function | Suitability |
|---|---|---|
| Cattle Feed | Antimycotic, preservative | High |
| Dog and Cat Food | Preservative, mold inhibitor | High |
| Granulated Feeds | Antimycotic agent | High |
| Vitamin Capsules | Secondary glycogen source | High |
| Milk Fever Prevention | Effective in preventing milk fever in cattle | High |
4.3. Cosmetics and Personal Care
| Application | Function | Suitability |
|---|---|---|
| Cosmetic Products | Prevents bacterial growth | High |
| Personal Care Products | pH control | High |
4.4. Pharmaceutical
| Application | Function | Suitability |
|---|---|---|
| Powder Formulations | Antimicrobial agent | High |
| Aloe Vera Therapy | Delays mold formation | High |
| Infection Treatments | Key role | High |
4.5. Photography and Coatings
| Application | Function | Suitability |
|---|---|---|
| Photographic Chemicals | Production and processing | High |
| Photographic Materials | Processing | High |
| Paint and Coating Chemicals | Surface treatment agent | High |
4.6. Agriculture
| Application | Function | Suitability |
|---|---|---|
| Insecticides | Pesticide chemical | Moderate |
| Processed Vegetables and Fruits | Anti-browning agent | High |
SECTION 5: INDUSTRY SUITABILITY MATRIX
| Industry | Suitability | Explanation |
|---|---|---|
| Food Industry | High | Preservative, mold inhibitor (E282) |
| Bakery | High | Bread, dough, bakery products |
| Animal Feed | High | Antimycotic, preservative |
| Veterinary | High | Milk fever prevention, vitamin additives |
| Cosmetics | High | Anti-bacterial, pH control |
| Pharmaceutical | High | Antimicrobial, infection treatment |
| Photography | High | Chemical production and processing |
| Coatings | High | Surface treatment agent |
| Beverages | High | Inhibiting agent |
| Agriculture | Moderate | Pesticide, anti-browning agent |
SECTION 6: OTHER NAMES AND IDENTIFIERS
| Type | Name / Description |
|---|---|
| IUPAC Name | Calcium propanoate |
| E Number | E282 |
| Commercial Names | Calcium Propionate, Calcium Propanoate |
| Synonyms | Calcium Dipropanoate, Propanoic Acid Calcium Salt, Propionic Acid Calcium Salt Hydrate |
| CAS Number | 4075-81-4 |
| EC Number | 223-795-8 |
| HS Code | 29155000 |
SECTION 7: TOXICOLOGY AND HEALTH EFFECTS
| Parameter | Value / Description |
|---|---|
| GHS Classification | Not classified (low toxicity) |
| Oral LD50 (Rat) | > 5,000 mg/kg |
| Dermal LD50 (Rabbit) | > 2,000 mg/kg |
| Skin Irritation | Mild irritant |
| Eye Irritation | Mild irritant |
| Skin Sensitization | Not sensitizing |
| Mutagenicity | Negative |
| Carcinogenicity | Not classified |
| Target Organs | Skin, eyes, respiratory system (dust) |
| Metabolism | Normal intermediate in animal metabolism |
SECTION 8: SAFETY AND STORAGE
| Parameter | Information |
|---|---|
| Storage Conditions | Cool, dry, well-ventilated area |
| Temperature | < 30°C |
| Container | Tightly closed, original packaging |
| Special Requirements | Hygroscopic; protect from moisture |
| Materials to Avoid | Strong oxidizers, moisture |
| Shelf Life | 24 months (under recommended conditions) |
| Packaging | 25 kg bags, 500 kg big bags |
SECTION 9: TRANSPORT INFORMATION
| Parameter | Information |
|---|---|
| UN Number | Not regulated (not classified as dangerous goods) |
| Hazard Class | Not applicable |
| Packing Group | Not applicable |
| Proper Shipping Name | Calcium Propionate |
| ADR/RID | Not regulated |
| IMDG Code | Not regulated |
| IATA (Air) | Not regulated |
| Marine Pollutant | No |
SECTION 10: FIRE-FIGHTING MEASURES
| Parameter | Information |
|---|---|
| Fire Hazard | Combustible dust |
| Extinguishing Media | Water fog, CO₂, dry chemical, foam |
| Special Hazards | When heated, releases acidic and irritant fumes |
| Decomposition Products | CO, CO₂, propionic acid vapors |
| Protective Equipment | Self-contained breathing apparatus (SCBA), full protective clothing |
SECTION 11: ACCIDENTAL RELEASE AND CLEANUP
| Parameter | Information |
|---|---|
| Personal Protection | Gloves, safety goggles, dust mask |
| Ventilation | Increase ventilation |
| Cleanup Methods | Sweep while preventing dust formation; collect in sealed containers |
| Environmental Precautions | Prevent entry into drains |
| Waste Disposal | According to local regulations |
SECTION 12: FIRST AID MEASURES
| Exposure Route | Action |
|---|---|
| Inhalation | Move to fresh air. Seek medical attention if symptoms persist. |
| Skin Contact | Remove contaminated clothing. Wash with soap and plenty of water. |
| Eye Contact | Rinse with plenty of water for at least 15 minutes. Seek medical attention if irritation persists. |
| Ingestion | Do NOT induce vomiting. Drink plenty of water. Seek medical attention. |
SECTION 13: REGULATORY INFORMATION
| Region / Authority | Status |
|---|---|
| EU REACH | Registered |
| Turkey KKDİK | Registration required |
| USA TSCA | Listed |
| USA FDA | GRAS (Generally Recognized As Safe) - 21 CFR 184.1221 |
| EU Food Additives | Approved as E282 |
| EU Animal Feed | Approved |
| EINECS | 223-795-8 |
| WGK (Germany) | 1 (slight hazard to water) |
SECTION 14: SUMMARY AND CRITICAL WARNINGS
Product Summary
| Parameter | Value |
|---|---|
| Product | Calcium Propionate (E282) |
| CAS | 4075-81-4 |
| Appearance | White powder |
| Molecular Weight | 186.22 g/mol |
| Water Solubility | 1 g/10 mL (good) |
| Key Industries | Food, animal feed, cosmetics, pharmaceutical |
CRITICAL WARNINGS
-
Food Preservative (E282): Calcium propionate is a widely used food preservative in bread, bakery products, processed meats, and dairy products. Prevents mold and bacterial growth.
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Antifungal Mechanism: Hydrolyzes to free propionic acid in acidic media. Exhibits antibacterial effect on Aspergillus niger and gas bacilli. Limited effect on yeast, making it preferred in bakery products.
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Sodium Alternative: Helps reduce sodium levels in bread. Sodium propionate can be used as an alternative.
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Hygroscopic: Absorbs moisture. Must be protected from moisture during storage.
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Animal Feed: Used as antimycotic and preservative in cattle feed, dog and cat food. Effective in preventing milk fever in cattle.
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Safe Toxicology: Normal intermediate in animal metabolism. Low toxicity with LD₅₀ > 5,000 mg/kg.
-
High Temperature Sensitivity: Decomposes when heated, releasing acidic irritant fumes. SCBA required in case of fire.
-
Storage: Store in cool, dry, well-ventilated areas. Keep away from strong oxidizers.
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Regulatory Status: FDA GRAS, EU approved as E282. Registered under REACH.
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Alternatives: Sodium propionate (E281), potassium sorbate (E202), sorbic acid (E200) can be used in similar applications.
IMPORTANT DISCLAIMER: This Technical Data Sheet (TDS) is for informational purposes only and is based on available technical data. The user is solely responsible for determining the product's suitability for their specific application and for complying with all applicable local, national, and international regulations. For complete safety, storage, handling, transportation, disposal, and regulatory compliance information, always refer to the official Safety Data Sheet (SDS/MSDS) provided by the manufacturer/supplier. Users are responsible for testing the product in their own processes and applications. All local, national, and international regulations must be followed when working with Calcium Propionate.
