Mannitol, Osmitrol, Manna Sugar, Cordycepic Acid, Sea Crystal, Osmofundin, Maniton-S, D-Mannitol, L-Mannitol, E421, 69-65-8

Mannitol, Osmitrol, Manna Sugar, Cordycepic Acid, Sea Crystal, Osmofundin, Maniton-S, D-Mannitol, L-Mannitol, E421, 69-65-8

Product Information – Mannitol (E421)

Chemical Name: D-Mannitol
CAS Number: 69-65-8
Molecular Formula: C6H14O6
Molecular Weight: 182.17 g/mol
E Code: E421
Synonyms: Mannitol, Osmitrol, Manna Sugar, Cordycepic Acid, Sea Crystal, Osmofundin, Maniton-S, D-Mannitol, L-Mannitol

Physical and Chemical Properties

• Appearance: White crystalline powder or granules

• Taste/Odor: Sweet, mild odor

• Melting Point: 168 °C

• Boiling Point: 290–295 °C

• Solubility:

  • 216 g/L at 25 °C

  • In glycerin: 1 g / 18 mL

• Density: 1.52 g/cm³ (20 °C)

• Sweetness: About 50% sweeter than sucrose

• Structure: Hexahydric alcohol derivative, sorbitol derivative

• Non-cariogenic (does not cause tooth decay)

Natural Sources

• Naturally present in fruits and vegetables

• Found in fungi, serving as sugar and carbohydrate reserve

Applications

Pharmaceutical Industry:

• Used in chewable tablets due to non-hygroscopic properties

• Ingredient in medicated chewing gums

• Active in formulations for treating cerebral and ocular edema

• Diuretic drug production (enhances urine output)

• Applied in renal failure treatments to remove excess water and toxins

Food Industry:

• Anti-caking agent

• Flavoring agent in nuts

• Sweetener and taste enhancer

Industrial Uses:

• Component in antifreeze formulations (mannitol, sorbitol, maltitol, etc.)

• Improves water activity and inhibits crystallization, lowering freezing point

• Minor additive with monoethylene glycol to reduce engine wear

Key Features

• Non-cariogenic, safe for dental health

• Provides sweetness with lower caloric value than sucrose

• Stable and non-hygroscopic, ideal for solid dosage forms